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However, pretreatment with ERK1/2 pathway inhibitor (PD98059) or p38MAPK inhibitor (SB203580) partly decreases the expression of GGT mRNA V-2 induced by HNE in L2 cells (38)

Potential role of NAC in COVID-19 infection As mentioned above, since oxidative stress is a central mechanism of COVID-19 pathology, severity, and mortality, NAC was proposed to be administered to high-risk individuals with severe COVID-19 [56]

Heme iron, found in animal products like red meat, poultry, and fish, is more readily absorbed by the body

Concluding remarks and perspectives In the current review, we recapitulate the intricate functions of iron governing energy metabolism and modulating ferroptosis at the cellular and subcellular levels in the context of both physiology and pathology