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OMalley et al

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The periplasmic heme-binding protein and the inner membrane heme transporter have not yet been identified, while within the cytoplasm, heme is degraded by heme oxygenase (HemO), resulting in the release of iron (Zhu et al., 2000)

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)