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Nanocarrier-based delivery systems(e.g., G4-AB-DOX/CuS, Sor@Fe-MOF) represent the most promising frontier, addressing key limitations of both monotherapy and combination approaches (253)

Diversity analysis and adonis analysis showed that the composition of gut bacteria in the HGR group was significantly different from the other two groups, specifically in terms of Desulfobacterota at the phylum level, and Rikenellaceae_RC9_gut_group , Ruminococcus , and Paeniclostridium at the genus level

In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]

Emerging studies suggest that individualized dosing strategies and otoprotective agents may reduce the severity of platinum-based drug-induced ototoxicity (Romano et al