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An intradermal test dose is recommended if there is a suspicion of allergy to cyanocobalamin

At the same time, the available publications mainly concern preclinical models and metabolic studies on the analogue of the AOD9604 , therefore interpretation of the results should take into account the experimental nature of this molecule and the fact that the scope of modern, high-quality clinical data is limited

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Intracellular ROS levels were assessed using 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA) staining and flow cytometry, revealing a 9.1-fold increase in ROS production in methamphetamine-treated SH-SY5Y cells