hepatic glutathione synthesis Two-step enzymatic reaction of glutathione

This precision medicine paradigm aims to optimize prevention and treatment strategies by considering the unique biochemistry of each patient

Morphological changes of mitochondrial are the important hallmark of ferroptosis, and studies have shown that mitochondria play an important role in the regulation of ferroptosis via regulation of energetic metabolism, iron metabolism, and other pathways (115, 116)

[DOI] [PubMed] [Google Scholar] 76.Sitta A, Vanzin CS, Biancini GB, Manfredini V, de Oliveira AB, Wayhs CA, Ribas GO, Giugliani L, Schwartz IV, Bohrer D, Garcia SC, Wajner M, Vargas CR

ROS are signalling molecules that influence many processes [10], and can initiate inflammatory responses through the activation of various signal transduction pathways and transcription factors, leading to increased gene expression of inflammatory target proteins [14] (Fig