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In a March 2021 article, two New York clinicians reported on the diagnosis and treatment for bacterial infections of necrotizing fasciitis (NF) in three dogs

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To counter the direct toxicity, there is an endogenous lipase or acyloxyacyl hydrolase in the liver and spleen of the host that selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides and prevents their recognition by the mammalian signalling receptors