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10.1126/science.6338593 Science 156 TekinS
With the absence of Wnt signal, GSK3 adds phosphate molecules onto serine-threonine residues of -catenin
(2024), intravesicular (bladder) injections of BPC-157 were reported to result in 80100% resolution of moderate to severe interstitial cystitis at 6 weeks post- treatment [65]
When Wnt proteins bind to their cell-surface receptors (Frizzled and LRP5/6), the destruction complex is inhibited, allowing -catenin to accumulate and enter the nucleus, where it activates Wnt target gene expression through interaction with T-cell factor (TCF) transcription factors
