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Chronic exposure to sertraline was shown to down-regulate expression of drug- and arachidonic acid-metabolizing enzymes in hepatic tissue, indicating that patients using this drug may be at risk of hepatotoxicity with reduced capacity to metabolize drugs and fatty acids (Almansour et al
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Although there are studies that have shown an increase in plasma L-carnitine after supplementation, only few studies have shown a subsequent increase in muscle [134,135]
Finally, Kogelnik et al
