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Melatonin, implicated in signaling the biological night to various cells by inducing hypothermia and promoting sleepiness [207, 208], may lower the release of the wake-promoting neuropeptide orexin, according to animal research [209]

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IGF-1 elevations followed, increasing 1.5 to 3-fold for 9 to 11 days after a single dose

doi: 10.1007/978-3-030-73234-9_1 222
