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Immunogenicity and toxicity of AAV gene therapy

Notably, CD117 + primary HSPCs were also killed, demonstrating an effective way to deplete HSPCs in vitro [119]

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Instead, we utilised the high nucleophilic reactivity of RSS and RS(S) n S (due to their low pK a and the -effect of the non-terminal sulfur atom) that enables reaction with iodoacetamide (IAM) to generate reaction products that incorporate the terminal sulfane sulfur (Fig