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Marketing Authorization Holder and Manufacturer Manager Marketing Authorization Holder Teva Pharma SLU C/Anabel Segura 11, Albatros B Building 1st floor 28108 Alcobendas, Madrid (Spain) responsible for manufacturing Pharmaceutical Works POLPHARMA SA Pelplinska 19 83-200 Starogard Gdaski Poland either RONTIS HELLAS MEDICAL AND PHARMACEUTICAL PRODUCTS SA PO BOX 3012 Larisa Industrial Area, Larissa, 41004 Greece Date of last revision of this leaflet: January 2022 Updated detailed information on this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) MORE USEFUL INFORMATION Risks of being overweight Being overweight will affect your health and increase your risk of developing serious health problems such as: Hypertension Diabetes Heart disease Stroke certain types of cancer Osteoarthritis Talk to your doctor about the risk of developing these diseases

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Tumor-Stroma mechanics coordinate amino acid availability to sustain tumor growth and malignancy