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The physiological response to exogenous testosterone is further modulated by individual genetic variability, particularly polymorphisms of the androgen receptor gene, which contribute to substantial interindividual differences in efficacy and adverse effect profiles (12)

renal function should be monitored if persistent vomiting or diarrhoea occurs Individuals with eating disorders or a history of disordered eating : Significant appetite suppression may exacerbate underlying psychological relationships with food Healthcare professionals should conduct a thorough medical history and risk assessment before enrolling patients in trials or, in future, prescribing retatrutide