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This NADPHGSH axis probably complements the ER peroxidases GPX7 and GPX8 that use H 2 O 2 to re-oxidize oxidoreductases, such as PDI, thereby lowering ROS levels 27

For example, in colon cancer cells (PC-3 cell line), at curcumin concentrations ranging from 0 to 50 M, treatment was associated with decreased phosphorylation of Akt kinase (Akt), mammalian target of rapamycin (mTOR), glycogen synthase kinase (GSK3), Forkhead box protein O1 (FOXO1), and other proteins (Yu et al., 2008)

Bells Palsy is a neurological condition that strikes unexpectedly, causing sudden weakness or paralysis of the facial muscles, typically on one side of the face

PMID: 33294265 medRxiv2026 Apr 18