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Tell your prescribing doctor if you have any of these conditions, which can increase B12 shot side effects: An allergy to cobalt Kidney disease Severe megaloblastic anemia Side Effects from B12 Shots The most common B12 shot side effect is swelling at the injection site

Well cover: Who actually benefits from B12 shots How often injections are given (loading and maintenance) How shots compare to oral and sublingual B12 Potential side effects and safety tips Smart ways to choose between options if youre vegan or have absorption issues Short answer: B12 shots are most helpful for diagnosed deficiency or poor absorption