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Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes
PloS One (2017) 12:e0189310
NMJ dysfunction and instability is a frequently encountered electrophysiologic finding in the evaluation of ALS [282]
DRAW up a rolling five-year development plan and annual estimates for the district
