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Environmental metabolic perturbations were apparent in the NHP (cohort 2) NMR data as demonstrated by the lack of a consistent metabolic signature observed in the SUS analysis (Supplementary Fig

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Microbial signatures in dysbiosis include reduced abundance of SCFAproducing bacteria (e.g., Faecalibacterium prausnitzii ) and beneficial genera like Akkermansia and Roseburia (Louis and Flint 2009

Protective effects of black raspberry ( Rubus occidentalis ) extract against hypercholesterolemia and hepatic inflammation in rats fed high-fat and high-choline diets