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10.1016/j.neuropharm.2005.06.015 Neuropharmacology 107 PeckE

25 Therefore, elevated blood tyrosine levels in HT-1 are more likely due to a secondary inhibition of proximal steps in tyrosine degradation and not the deficiency of FAH

69, 168 Expression of mouse carbohydrates and lipids on xenografted human tumor cells has also been described and could potentially alter the response of such tumors to the metabolic microenvironment

2.5.2 Clinical studies Monogenic PD cases due to GBA1 loss of function and subsequent substrate accumulation have been investigated in cellular and animal models and in studies of human brains of patients with GBA1 -associated PD showing to particularly affect pars compacta of SN, putamen, cerebellum, and amygdala and frontal cortex (Gegg et al., 2012
