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The Journal of Neuroscience, 41, 215233
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They identified the iron storage protein, ferritin light chain 1 (FTL1), as a pro-ageing neuronal factor: its overexpression in the hippocampus of young mice accelerated cognitive decline, whereas knockdown in aged mice preserved synaptic integrity and prevented cognitive deterioration
These findings highlight the imperative for predictive models that evaluate present reproductive status while also forecasting future risks by accounting for both direct environmental influences and heritable epigenetic alterations
