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Methadone , a full opioid agonist, has decades of evidence supporting its effectiveness, particularly in cases of high-severity opioid dependence

174, 175 In the absence of placebo controls, it is difficult to know the size of the true treatment effect and the precise balance between benefits and risks/burdens

This is a great question, and the answer really depends on your body and what you're hoping to achieve

Change 12 , 228231 (2022)
