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Notably, while classical organoid systems have long been established exclusively from crypt-resident stem cells 27,28 , our findings challenge this longstanding paradigm by demonstrating that mutation-free villus-derived cells can indeed establish organoids via fetal reversion, revealing remarkable regenerative flexibility of the adult intestinal epithelium

Certain elements of air pollution can cause health impacts through immunological, inflammatory, and excessive oxidative stress pathways

Additional file 4: Fig
