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Typical features include rapid vertical growth and ulcer development within the lesion.[19,22] Melanoma of the oral cavity may occur with or without a radial growth phase and it may clinically classified as Pigmented nodular Nonpigmented nodular Pigmented macular Pigmented mixed Nonpigmented mixed type.[7] The prognosis of oral mucosal melanoma is usually poor, as a result of rapid growth and delayed diagnosis

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269 the expressed cDNAs of two heme dioxygenase-P450 fusion proteins converted LA to the 10( S )-HpODE