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[54] revealed that the heteropolysaccharide fraction of Hericium erinaceus not only increased the spleen index in mice subjected to Cy but also upregulated the activation of natural killer (NK) cells and promoted the proliferation and activation of T and B lymphocytes in immunosuppressed mice, as well as enhancing the phagocytic activity of peritoneal macrophages, thus improving overall immunity

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17,18,19 In addition, activated DVL recruits AXIN and GSK-3 to the plasma membrane and inhibits their functions

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