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To potentially prevent or slow down LA fragmentation by the brush-border enzymes responsible for LA fragmentation, chiral modification of the entire LA sequence to all D amino acids was conducted, which resulted in the generation of LA Analog 6 (A6) by Innovate Biopharmaceuticals, Inc

Cunha-Oliveira T, Montezinho L, Mendes C, Firuzi O, Saso L, Oliveira PJ, et al
doi: 10.1126/science.1153795

The answer often comes down to peptide vs GLP-1 mechanism
