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Thus, NACs neuroprotective effects may involve its ability to reduce cortical spermidine levels and thereby limit local excitotoxic effects in the PFC during THC exposure, further indicated by our electrophysiological findings demonstrating a hyperactive neuronal mPFC phenotype

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However, there are large discrepancies in the effects and the dose-response relationship, even at doses higher than the ULs (Bendich and Machlin, 1988)