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Therapy-induced senescent cells can re-enter the cell cycle to show aggressive proliferative and cancer stem-like properties, presenting a risk for recurrence and treatment resistance

Members of the TGF- superfamily (TGF-1/2/3, GDF-5, and GDF-6) can all promote MSC differentiation towards NP-like cells, with GDF-6 having a particularly significant effect, inducing richer proteoglycan ECM synthesis, and showing more pronounced effects in AD-MSCs compared to BMSCs (Stoyanov et al., 2011

In a model of chronic neurodegeneration, Thomsen et al

Apodaca, G., Gallo, L
