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reported that hydrogen sulfide-induced GAPDH sulfhydration leads to its redistribution into the nucleus and interaction with CCAR2 inside the nucleus, which disrupts the inhibitory effect of CCAR2 on SIRT1 and unltimately activated-SIRT1 deacetylates microtubule-associated protein 1 light chain 3 beta (MAP1LC3B/LC3B) to induce its translocation from nucleus to cytoplasm and activate autophagy (61)