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It is a synthetic 39-amino acid peptide that acts as an agonist at both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), producing synergistic metabolic effects that exceed those of selective GLP-1 agonists in clinical trials

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Mice were euthanized via isoflurane asphyxia followed by cervical dislocation 1516 hours after CLP for the metabolomics and cytokine assays, and seven days after CLP for body weight and survival studies

Preparation of multifunctional drug carrier for tumor-specific uptake and enhanced intracellular delivery through the conjugation of weak acid labile linker