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However, in inflammatory models, trained immunity may aggravate disease, for instance, in dextran sulfate sodium-induced colitis, Mincle-deficient mice displayed milder pathological symptoms, indicating that trained immunity contributes to the pathology of inflammatory bowel disease (142)

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These now stripped molecules are now unstable and often referred to as free radicals. Once the process of a volatile free radical cell begins, a chain reaction is likely to cascade through hundreds of more cells until the radicalized cells eventually die or mutate