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Despite substantial global research investment, the clinical development failure rate for true disease-modifying osteoarthritis drugs (DMOADs) remains exceedingly high, with over 90% of candidate drugs failing to achieve clinical translation (5, 6)
This dual agonism increases satiety signals, slows gastric emptying, and enhances insulin secretion
Chemotherapeutic medicines can be detoxified by them as well, for instance, GSTP1 contributes to chemoresistance in ovarian and other forms of cancer
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