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Both excesses and deficiencies of certain nutrients, as well as exposure to heavy metals, toxins, and endocrine disruptors, can disrupt immune tolerance

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Inflammation can occur in any joint in the body, but some of the most common joints that become inflamed and painful are in the spine, especially the lumbar region (lower back), and in the knees, shoulders and hips

[55] observed a negative correlation between vitamin B12 levels and the Toronto Clinical Scoring System score used for diagnosing peripheral neuropathy