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Earlier work in Planta Medica showed that madecassoside increases collagen synthesis and reduces inflammatory infiltration in vivo (Liu et al., 2008)

Additionally, a clinical trial conducted by Watanabe et al
Cellular senescence or stemness: hypoxia flips the coin

Int J Inst Pharm Life Sci 5(1):205231 Silvestri D, Mikek J, Wacawek S, Torres-Mendieta R, Padil VVT, ernk M (2019) Production of electrospun nanofibers based on graphene oxide/gum Arabic