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The most effective approach is often whats called an orthomolecular approach
7, 8, 9, 10, 11 Often, these regulated mechanisms are challenged by both the environment and genetic susceptibility factors

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Yin L, Ouyang D, Lin L et al (2021) Salidroside regulates imbalance of Th17/Treg and promotes ischemic tolerance by targeting STAT-3 in cerebral ischemia-reperfusion injury