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A single-nucleotide polymorphism (sA158G rs4680) in the COMT gene also led to a greater risk of LDopa-related PN in PwPD through low enzymatic activity (Toth et al
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Cell 4 , 12671275 (1993)
It also stimulates fibroblast proliferation in connective tissue, increasing collagen synthesis and improving the structural quality of the repair
