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Because PFKFB3 is upregulated in EGFR-TKI resistant NSCLC, PFK15 exhibits synergistic impact with erlotinib in wild type and EGFR mutant cell lines (Lypova et al., 2019)

See also [edit] References [edit] "Inorganic Cyanide as Protecting Group in the Stereospecific Reconstitution of Vitamin B 12 from an Artificial Green Secocorrinoid" (PDF)

DNA damage repair has attracted widespread attention due to its important role in the maintenance and regulation of germ cells

3.1.4 The hippo and other ferroptosis-related pathway and RCC The knockdown of MIT domain-containing protein 1 down-regulates TAZ (a downstream signaling factor of the Hippo pathway) and causes the inhibition of SLC7A11 expression, thereby inhibiting cellular cysteine uptake and inducing ferroptosis (92)