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Cellular hIAPP cytotoxicity can be activated from intracellular or extracellular sites
Furthermore, A is able to promote the hyperphosphorlyation of Tau in both the cytosolic and synaptic compartments, which has been suggested as a potential explanation of the prion-like seeding hypothesis of Tau transmission inter-neuronally, accounting for the phosphorylated Tau detected in the CSF of AD patients (Wu et al., 2018
however, it often remains moderate during this stage
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