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We also explore natural ways to eliminate it

Adipokines such as leptin and adiponectin are lower in HNSCCs patients (135138), whereas visfatin and chemerinze are higher (139).However, adipocytes distribution in different regions of HNSCCs varies, which may be the reason for the distinct metabolism CAFs subtypes in HNSCCs (128, 140)

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Although ED it is not a life-threatening disease, therapeutic management of ED should not be overlooked, since ED may negatively impact on couple relationship and general health, and even moderate improvements of vascular dysfunction might have a significant clinical impact