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Fang X, et al

At 10 mg, average weight loss jumped to 21.4%, roughly 47 pounds from the same starting weight
What the broader literature describes is remodeling, not a one-way pile-up
In particular, Akt phosphorylation, compared to ERK phosphorylation, appeared to be more sensitive to the phosphorylation of Met, which is evident by the dramatic reduction in pAkt in the case without 51 (Fig
