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In the dividing cells, passive DNA demethylation occurs as the depletion of Dnmt1 results in newly incorporated cytosine to remain unmethylated and consequent hypomethylation [65]

TGF-alpha as well as VEGF, PD-ECGF and bFGF contribute to angiogenesis of esophageal squamous cell carcinoma

Mol Nutr Food Res.2018;62(13):e1800147

It seems you may need high B12 supplementation and to stop any folate supplements for a while
