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IR is considered an underlying factor in PCOS, playing a crucial role in its pathogenesis

Appl , 11:1600190 10.1002/prca.201600190 183 ZhengY.HuF

Interestingly, Boccaccio showed in a mouse model that activation of the oncogene induced cancer and a thrombohemorrhagicsyndrome through transcriptional upregulation of the procoagulation factors plasminogen activator inhibitor type 1 (PAI-1) and cyclooxygenase-2 (COX-2)

Furthermore, cobalt-conjugated N-CQDs demonstrated efficient penetration into neuronal and non-neuronal tissues in zebrafish, a well-established non-mammalian vertebrate model, without eliciting detectable apoptosis or oxidative stress [157]