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The considerable amount of protein sequence variation has led to the general belief that GSTs carry out a very wide variety of glutathione-dependent conjugation functions

However, ILADS CLD is a symptom-based definition and therefore ongoing infection is difficult to assess in individual patients with no currently available biomarker test, and given the large degree of symptom overlap between CLD and other illnesses

The study also found that glutathione levels began to return to baseline approximately one month after supplementation ceased, indicating that consistent use is key to maintaining optimal levels

Mahalle et al., 2025)