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N Engl J Med 318(26):17201728 Devalia V et al (2014) Guidelines for the diagnosis and treatment of cobalamin and folate disorders
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IV therapy is extremely beneficial for patients experiencing fatigue, chronic illness, brain fog, difficulty losing weight, chronic dehydration, inflammatory conditions, migraines and/or chronic headaches, or patients wanting assistance detoxing

Short-term storage at 28C is acceptable for active research periods but will shorten overall shelf life and is not recommended once the vial has been opened