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33, 35, 39, 40 Biochemically, untreated individuals may exhibit metabolic ketoacidosis, lactic acidosis, and/or hyperammonemia

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They are essential for many biological functions, such as development and tissue remodeling in both healthy and pathological conditions

Through intricate crosstalk with these diverse signaling cascades, HIF-1 modulates the secretion of inflammatory factors and participates in the regulation of various cellular processes, including survival, proliferation, metabolism, angiogenesis, and inflammatory responses