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One potential mechanism that could account for estrogen effects on the intestine is through its alterations in TJ and adhesion molecules which would alter intestinal permeability [94]

The primary outcomes of this study were the pharmacokinetics parameters of caffeine, which were the maximal plasma concentration ( C max ), the time to the maximal plasma concentration ( T max ), the area under the plasma concentration-time curve from time 0 to 12 h (AUC 012 ) and from time 0 to infinity (AUC 0 ), and the half-life ( t 1/2 )

doi: 10.1111/ jfbc.12935

The phosphorylated Smad2/3 then associates with, and moves to, Smad4, thereby triggering the transcription of TGF-responsive genes (71)
