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A Study of Once-Daily Oral Orforglipron vs Oral Semaglutide in Participants With Type 2 Diabetes (ACHIEVE-3)

So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets

We need a deeper understanding of how the things we ingest combined with our skin bacteria can lead to certain diseases and what we can do about it to prevent those illnesses

Additionally, reducing visceral fat can lower the risk of heart disease by promoting heart-healthy eating, controlling hypertension, and encouraging physical activity