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doi: 10.1371/journal.pone.0075493
Recent research has demonstrated that pH levels in the TME significantly impact immune cell function, cytokine secretion, and ammonium metabolism reprogramming, which may contribute to the decreased pH value in the TME (269)
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However, studies have proposed NO to represent a double-edged sword with its overproduction leading to a multitude of NO by-products implicated in mutational events and carcinogenesis
