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In a clinical trial sacubitril/valsartan was shown to be an effective treatment for heart failure with reduced ejection fraction and side effects comparable to the ACE inhibitor enalapril (113)
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Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation

Membranes were immunoblotted by using the SNAP i.d
