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NO-mediated activation of soluble guanylate cyclase (sGC) stimulates synthesis of cyclic GMP (cGMP), which in turn binds to and activates protein kinase G (PKG)
For example, orally administered Schisandra chinensis lignans must endure changes in pH and enzymatic activity as they pass through the GI system before reaching target sites such as colon cancer cells
[PMC free article] [PubMed] [Google Scholar] 181.Ding JH, Li SP, Cao HX, Wu JZ, Gao CM, Liu YT, Zhou JN, Chang J, Yao GH
