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You have to put in several punishing hours a day, control your eating habits, quit alcohol and smoking, and, in some cases, even forgo the occasional candy

As an example, it has been demonstrated that a mutation (S662G) in PER2, which is known to be responsible for the familial advanced sleep phase syndrome, increased resistance to apoptosis and E1A- and RAS-driven oncogenic transformation, as well as affected tumorigenesis in p53 R172H/+ mice, with a cancer-sensitized genetic background 38

7 Although some innovative therapies, such as PROTAC technology, can efficiently degrade AR proteins, their effects on AR-V7 are relatively weak