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Potential therapeutic applications of catalase mimics As discussed above, hydrogen peroxide is formed from superoxide radical anions either spontaneously or by rapid enzymatic (SOD) dismutation

For long-term use, serum copper and ceruloplasmin would need monitoring, and gene expression effects evaluated since GHK can downregulate overexpressed cancer-associated RNAs

This allows for robust identification of structural homologs, revealing subtle variations in folds, loop regions, and cavity architectures that refine existing classifications and can identify novel structural subgroups (Gonalves et al., 2024a

U-shaped association between dietary copper intake and new-onset hypertension