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These findings with catalase suggest that excess GPx-1 may potentiate apoptosis as a consequence of the disruption of normal (adaptive) oxidant signaling ( i.e ., a reductive stress leading to lack of survival) and not by other properties of GPx-1

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Karp DD, Hanneken JM, Taylor SH, Liu S, Johnson ED, Wistuba II, Swisher SG , Munden RF, Stewart DJ

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All reagents for cell culture were obtained from Invitrogen (Life Technologies, Carlsbad, CA, USA)

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